ANTIEPILEPTIC DRUGS PHARMACOLOGY PDF DOWNLOAD
ANTIEPILEPTIC DRUGS PHARMACOLOGY PDF DOWNLOAD!
Antiepileptic drugs (AEDs) are the mainstay of treatment for the majority of of the clinical pharmacology of these agents, including their mechanisms of action. Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review Pharmacological Reviews July , 68 (3) ; DOI. Intravenous (i.v.) administration of antiepileptic drugs. (AEDs) produces the most rapid onset of action, as it is delivered directly into the bloodstream and.
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Knowledge of drug mechanisms is important for choosing the proper drug for various seizures types.
Pharmacology of antiepileptic drugs.
In addition, an understanding of antiepileptic drug pharmacokinetics, nontherapeutic effects, and interactions is essential for optimal therapy. The Journal of Clinical Psychiatry.
Work Group on Borderline Personality Disorder. Some metabolites are themselves active carbamazepine, oxcarbazepine, primidone. Gabapentin undergoes no antiepileptic drugs pharmacology and is excreted unchanged by the kidney.
Most AEDs are metabolized by the P enzyme system in the liver. Different AEDs either induce or inhibit certain isoenzymes of this system and can result in changes of the pharmacokinetic properties antiepileptic drugs pharmacology different medications Table 2.
In general enzyme inducers decrease the serum concentrations of other drugs metabolized by antiepileptic drugs pharmacology system and enzyme inhibitors have the opposite affect. Valproic acid is metabolized by a combination of conjugation by uridine glucuronate UDP -Glucuronyltranferase UGT via conjugation and by mitochondrial beta-oxidation.
Pharmacology of antiepileptic drugs. Several different types of chemical compounds are useful as antiepileptic drugs. If valproic acid is added to a patient antiepileptic drugs pharmacology is already taking phenytoin, the phenytoin is displaced from albumin binding antiepileptic drugs pharmacology, resulting in a higher free fraction and toxicity.
Metabolism Most AEDs are metabolized in the liver by hydroxylation or conjugation. These metabolites are then excreted by the kidney.
Some metabolites are themselves active carbamazepine, oxcarbazepine, primidone. Gabapentin undergoes no metabolism and is excreted unchanged by the kidney.
Most AEDs are metabolized by the P enzyme system in the liver.